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The anthracycline antibiotics: Antitumor drugs that alter chromatin structure

Article Abstract:

The molecular mechanisms involved on the interaction of anthracycline antibiotic drug used in cancer chemotherapy with chromatin and its components, DNA and histones are reviewed. The study suggests that one very important component of the activity of these drugs is the result of these manifold interactions that lead to a chromatin unfolding and aggregation.

Author: Finn, Ron M., Rabbani, Azra, Ausio, Juan
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2005
Usage, Chromatin, Cancer, Anthracyclines, Chemotherapy

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Dynamic regulation of DNA methylation coupled transcriptional repression: BDNF regulation by MeCP2

Article Abstract:

A recurrent theme in eukaryotic genome regulation stipulates that the properties of the DNA are strongly influenced by the nucleoprotein complex into which it is assembled. The modulation of both DNA methylation itself, as well as the machinery implicated in its interpretation , are involved in acute gene regulation.

Author: Wade,Paul A.
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
Nucleoproteins, Genetic regulation, Chemical properties

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DNMT cooperativity-the developing links between methylation, chromatin structure and cancer

Article Abstract:

The biological significance of gene expression with emphasis on the impact of DNA methylation and the enzymology of DNA methyltransferases in cancer are discussed. Studies reveal that the methyltransferases DNMT1 and DNMT3b cooperatively maintain DNA methylation and gene silencing in human cancer cells.

Author: El-Osta, Assam
Publisher: John Wiley & Sons, Inc.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2003
Cancer cells, Genetic research, Methylation, Methyltransferases

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Subjects list: Research, DNA
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