The blood-brain- barrier: Lessons from moody flies
Article Abstract:
The identification of moody, a gene required for the formation and maintenance of the Drosophila blood-brain barrier, (BBB) provides new insight into how paracellular junctions are formed at the barrier. Moody is identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability
Article Abstract:
Moody is identified in a genetic screen for Drosophila mutants with altered cocaine sensitivity. A Moody-mediated signaling pathway functions is proposed in glia to regulate nervous system insulation and drug-related behaviors.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events. Golgi membranes remain segregated from the endoplasmic reticulum during mitosis in mammalian cells
- Abstracts: Clinical and environment isolates of Legionella pneumophila serogroup 1 cannot be distinguished by sequence analysis of two surface protein genes and three housekeeping genes
- Abstracts: Structural and functional differences in two cyclic bacteriocins with the same sequences produced by lactobacilli
- Abstracts: A microRNA meditates EGF receptor signaling and promotes photoreceptor differentiation in the drosophila eye. A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila
- Abstracts: Impaired maternal behaviour in mice lacking norepinephrine and epinephrine. A distinct role for Norepinephrine in memory retrieval