The body language of cells: the intimate connection between cell adhesion and behavior
Article Abstract:
One class of cell adhesion junctions are mediated by the cahedrin subgroup of Wnt proteins. In this model, two cells with matching cahedrins approach and touch. The cahedrins begin to make a cahedrin zipper which is stabilized extracellular and cytoplasmic factors, especially beta-catenin and PKG. The zipper becomes the cytoplasmic plaque which is further stabilized by microfilaments attaching to the cytoskeletons. A cytoplasmic beta-catenin/PKG complex either liberates or forms a complex with protein X, which reacts to Wnt signals and regulates the genetic expression of the adhesion process.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis
Article Abstract:
Maintenance of glucose at normal levels requires pancreatic beta cell glucokinase (GLK) for phosphorilation in the glucose catabolic pathway. Mice bred with one functional GLK allele exhibited a weak beta cell response to glucose and had hyperglycemia. These mice produced GLK only in pancreatic cells and not in the liver. Mouse pups without the GLK allele had extreme hyperglycemia and died a few days after birth.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Control of cell proliferation and apoptosis by Mob as tumor suppressor, Mats
Article Abstract:
The growth inhibitory functions for Mps one binder (Mob) superfamily protein, termed as mob as tumor suppressor (Mats), in drosophila is described. The loss of Mats functions results in increased cell proliferation, defective apoptosis, and induction of tissue growth and Mats physically associates with Warts proteins to stimulate the catalytic activity of the Warts Kinase.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
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