The complexity of p53 modulation: emerging patterns from divergent signals
Article Abstract:
Functional inactivation of p53, a cellular protein critical in malignant disease and other situations, a tumor suppressor gene, makes a mammal cell susceptible to environmental hazards and oncogenic stimuli that promote malignant progression and growth deregulation. Inactivation can be achieved by protein degradation, viral oncogene binding, or gene mutation/deletion. The protein protects a cell against neoplastic transformation. A number of mechanisms have evolved to regulate activity of p53, not surprising, since it is a very important to the cell, responds to stress, such as UV radiation, decreased rNTP, and hypoxia, and to DNA damaging agents.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Defective potassium currents in ataxia telangiectasia fibroblasts
Article Abstract:
Defective potassium ion channel activity has been implicated in ataxia telangiectasia (AT) cells. In comparison with control fibroblasts, AT fibroblasts have less ability to depolarize in the presence of increasing concentrations of extracellular K+. A lack of outward rectifier K+ currents in AT fibroblasts is indicated by electrophysiological measurements. Transfection with full-length ATM cDNA corrects the K+ current abnormalities in AT fibroblasts.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
CDK inhibitors p18INK4c and p27Kip1 mediate two separate pathways to collaboratively suppress pituitary tumorigenesis
Article Abstract:
CIP/KIP and INK4 are distinct families of cyclin-dependent kinase (CDK) inhibitors. They are implicated in mediation of a wide range of cell growth control signals. Mice that lack p18INK4c develop widespread organomegaly and gigantism. CDK inhibitors p18INK4c and p27Kip1 mediate two pathways to suppress pituitary tumorigenesis in collaboration.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The role of the genome project in determining gene function: insights from model organisms. The aftermath of scientific fraud
- Abstracts: Genetic control of cell division patterns in developing plants. Development of a core RFLP map in maize using an immortalized F2 population
- Abstracts: The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species
- Abstracts: Statistical modeling of methane production from landfill samples. Inhibition of methanogenesis by methyl fluoride: studies of pure and defined mixed cultures of anaerobic bacteria and Archaea
- Abstracts: The role of environmental factors in the regulation of virulence-determinant expression in Staphylococcus aureaus 8325-4