The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping

Article Abstract:

The critical region for Behcet disease in the human major histocompatibility complex (MHC) has been narrowed to a 46-kb segment centromeric of HLA-B (ital). Association analysis for Behcet disease has been carried out on eight polymorphic microsatellite markers over a 900-kb region around the HLA-B (ital) locus of the MICA (ital) gene. The HLA-B51 allele is associated with the disease, which has a frequency of 45%-60% in Asian and Eurasian ethic groups, is an inflammatory disorder that occurs spontaneously, and is often triggered by environmental factors.

United States, Japan, Usage, Physiological aspects, Behcet's disease, Behcet's syndrome, Major histocompatibility complex, Chromosome mapping, Genetic disorders

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Genomewide association analysis of human narcolepsy and a new resistance gene

Article Abstract:

A genomewide association study is performed using microsatellite markers in order to discover additional candidate regions for susceptibility or resistance to human narcolepsy. The reporter-gene assays have showed that the marker D2IS0012m in the promoter region and the SNP rs 13046884 in the intron of NLC1-A affected expression levels significantly and hence the NLC-1 is considered to be a new resistance gene for human narcolepsy.

Gene expression, Genetic research, Narcolepsy, Genetic susceptibility

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Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism

Article Abstract:

Various studies are performed to reveal the disease-causative gene of X-linked dystonia-parkinsonism (XDP). The genome sequencing analysis and expression analysis have shown that the reduced neuron-specific expression of the TATA-binding protein-associated factor 1 gene (TAF1) is associated with XDP.

DNA binding proteins, Parkinsonism, Dopamine receptors, Dystonia, Structure, Report

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