The critical region for Behcet disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping
Article Abstract:
The critical region for Behcet disease in the human major histocompatibility complex (MHC) has been narrowed to a 46-kb segment centromeric of HLA-B (ital). Association analysis for Behcet disease has been carried out on eight polymorphic microsatellite markers over a 900-kb region around the HLA-B (ital) locus of the MICA (ital) gene. The HLA-B51 allele is associated with the disease, which has a frequency of 45%-60% in Asian and Eurasian ethic groups, is an inflammatory disorder that occurs spontaneously, and is often triggered by environmental factors.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 1999
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Genomewide association analysis of human narcolepsy and a new resistance gene
Article Abstract:
A genomewide association study is performed using microsatellite markers in order to discover additional candidate regions for susceptibility or resistance to human narcolepsy. The reporter-gene assays have showed that the marker D2IS0012m in the promoter region and the SNP rs 13046884 in the intron of NLC1-A affected expression levels significantly and hence the NLC-1 is considered to be a new resistance gene for human narcolepsy.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
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Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism
Article Abstract:
Various studies are performed to reveal the disease-causative gene of X-linked dystonia-parkinsonism (XDP). The genome sequencing analysis and expression analysis have shown that the reduced neuron-specific expression of the TATA-binding protein-associated factor 1 gene (TAF1) is associated with XDP.
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
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