The destinies and destinations of RNAs
Article Abstract:
Topics discussed in the third biennial FASEB Summer Research Conference with a theme 'Intracellular RNA Sorting, Transport and Localization' are reviewed. Some of these topics include the biological role of RNA localization, the characteristics of cis-acting RNA localization signals, the proteins that bind RNA localization components, the functions of the cytoskeleton, motor proteins and cellular organelles in RNA, localization of RNA by degradation as well as in response to extracellular signals, and nuclear and cytoplasmic RNA transport. Directions of future research in this field are discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
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A structural model for the HIV-1 Rev-RRE complex deduced from altered-specificity rev variants isolated by a rapid genetic strategy
Article Abstract:
A broadly applicable genetic method that exploits the power of Escherichia coli genetics is developed to identify Rev amino acid residues with the ability to recognize Rev response element stem-loop IIB. The method, which subjects IacZ expression to translational control by inserting a binding site for the protein, is applied to the HIV Rev-1 protein. Results provide genetic evidence of the direct contact between specific Rev amino acids and RNA nucleotides in the RNA complex of Rev.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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