The effect of family structure on linkage tests using allelic association

Article Abstract:

The power of the transmission-disequilibrium test (TDT) is substantially enhanced by sampling families with one affected parent. Families with two affected sibs are also highly valuable for such a study. However, once the parents have been genotyped, including information from unaffected sibs is unlikely to increase the test's power. The TDT is best understood as a test for linkage disequilibrium.

Linkage (Genetics)

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Linkage analysis in a large Brazilian family with van der Woude syndrome suggests the existence of a susceptibility locus for cleft palate at 17p11.2-11.1

Article Abstract:

Linkage analysis for van der Woude syndrome (VWS), a rare autosomal dominant orofacial disorder, carried out in a large Brazilian family is discussed. The study suggests existence of a susceptibility locus for cleft palate at 17p11.2-11.1 and will have important implications for genetic counselling and prediction of cleft palate risk.

Brazil, Statistical Data Included, Usage, Genetic aspects, Chromosome mapping, Cleft palate

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