The genetics of hereditary colon cancer
Article Abstract:
A study was undertaken to determine whether colon cancer was a hereditary phenomenon. Results revealed that the familial adenomatous polyposis (FAP), a rare autosomal disorder might be responsible for colon cancer in individuals.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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The molecular pathogenesis of pancreatic cancer: Clarifying a complex circuitry
Article Abstract:
The molecular pathogenesis of pancreatic ductal adenocarcinoma (PDAC or PDA) and precursor lesions is presented. The mouse models are used as a platform for molecular diagnostics, prognosis and targeted therapeutics.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
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The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation
Article Abstract:
Esophageal epithelial cells are used as a platform to recapitulate esophageal squamous cell cancer thereby providing insights into the molecular pathogenesis of squamous cell cancers.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
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