The homeoprotein nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

Article Abstract:

The pluripotency of embryonic stem and inner cell mass cells is examined in terms of genes expressed in mouse embryonic cells and preimplantation cells. Research reveals one of the genes encoding the homeoprotein, called Nanog, maintains pluripotency of both embryonic and inner cell mass cells wihout the leukemia inhibitory factor and Stat3 proteins.

Japan, Embryology, Animal embryology, Blastocyst

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Article Abstract:

Studies were conducted to demonstrate induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions. It was found that pluripotent stem cells could be directly generated from fibroblast cultures by the addition of only a few defined factors.

United States, Cell culture, Fibroblasts

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Functional expression cloning of nanog, a pluripotency sustaining factor in embryonic stem cells

Article Abstract:

Mouse embryonic stem cell propagation is mediated by a homeodomain protein, which serves as an effector of embryonic cell self-renewal. Data indicate that this homeobox gene encodes a homeoprotein, Nanog, which is expressed in founder cells of embryos.

Scotland, Gene expression

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