The long and short of hedgehog signaling
Article Abstract:
The hedgehog (hh) gene in Drosophila and the Sonic hedgehog (Shh) in vertebrates code for the formation of proteins which are crucial for embryonic segmentation and patterns in adult appendages. The HH and the SHH-N precursor proteins formed by the hh and Shh gene respectively cleave into a N-terminal and a C-terminal part. The N-terminal part controls the long- and short- range inductions and the C-terminal binds the proteins to the notochord and prevents it from diffusing out. The differentiation the cell undergoes depends on the concentration of HH and SHH-N.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Molecular dissection of Hox gene induction and maintenance in the hindbrain
Article Abstract:
Various experiments on the molecular dissection of Hox gene induction and maintenance in the hindbrain indicated complexities in the system of signals and responses influencing the nervous system. They showed the existence of separate mechanisms that support the expression of a gene accommodating positional addresses within the hindbrain. The use of classical experimental embryology and the dissection of enhancer elements is anticipated to reveal more information on genetics and epigenesis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
A molecular pathway determining left-right asymmetry in chick embryogenesis
Article Abstract:
Expression patterns of three genes, Sonic hedgehog, cNR-1 and activin receptor IIa, have been characterized that mediate left-right (LR) morphological asymmetry in chick embryos. The genes are asymmetrically expressed during and after gastrulation and mediate the expression of each other in a sequential pathway. The genes are part of a signalling cascade that effect heart situs. A model of the LR determination pathway is discussed.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Mesodermal and neuronal retinoids regulate the induction and maintenance of limb innervating spinal motor neurons
- Abstracts: The termite gut microflora as an oxygen sink: microelectrode determination of oxygen and pH gradients in guts of lower and higher termites
- Abstracts: Uptake and retention of Vibrio cholerae O1 in the Eastern oyster, Crassostrea virginica. Pulsed-field gel electrophoresis and ribotype profiles of clinical and environmental Vibrio vulnificus isolates
- Abstracts: Contact angle measurement and cell hydrophobicity of granular sludge from upflow anaerobic sludge bed reactors
- Abstracts: Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy