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The many faces of PPAR(gamma)

Article Abstract:

The nuclear receptor peroxisome proliferator- activated receptor gamma (PPARgamma) is targeted with greater benefit and with less risk to patients. The results depend upon the basic biology of PPARgamma, and the possibility of selectively modulating the activity of the nuclear receptor in a tissue- and target-gene-specific manner.

Author: Lazar, Mitchell A., Lehrke, Michael
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2005
Science & research, Research, Cell proliferation, Peroxisomes

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Gaining weight: The Keystone Symposium on PPAR and LXR

Article Abstract:

The critical role of lipid-sensing receptors, Peroxisome Proliferator-Activated Receptors (PPARs) and Liver X Receptors (LXRs) in lipid and glucose metabolism is discussed in Keystone Symposium. The therapeutic manipulation of PPARs and LXRs has the potential to combat obesity and diabetes.

Author: Lazar, Mitchell A., Glass, Christopher K., Lehrke, Michael, Pascual, Gabriel
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
Genetic aspects, Keystone species

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Mechanisms of obesity-related insulin resistance: Many choices on the menu

Article Abstract:

The article takes a look at the biological factor possibly responsible for obesity-related insulin, the risks involved, treatment and prevention.

Author: Lazar, Mitchell A., Qatanani, Mohammed
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2007
Care and treatment, Prevention, Obesity, Insulin resistance

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Subjects list: Genetic research
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