The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

Article Abstract:

The mei-41 protein of the Drosophila melanogaster mei-41 gene bears a structural homology to the human ataxia telangiectasia-mutated (ATM) protein and to the yeast Mec1p and rad3 proteins. A functional similarity also exists between mei-41 and ATM. The mei-41(super +) gene product is needed for a radiation-initiated late cell cycle arrest and its absence enables many cells with damaged DNA to enter mitotic metaphase. The role of mei-41 protein in oogenesis and embryogenesis are discussed.

Homology (Biology)

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Yeast genetics and the fall of the classical view of meiosis

Article Abstract:

The classical view of meiosis states that the synaptonemal complex is essential for the initiation of recombination, which in turn results in proper segregation of paired chromosomes. However, new findings on Saccharomcyes cerevisiae have challenged this central dogma and are presented in a new model of meiosis. The differences between this model and the classical views are discussed, as well as the other possible roles of the synaptonemal complex in the meiotic process.

Models, Genetic recombination, Saccharomyces

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DNA binding and meiotic chromosomal localization of the Drosophila nod kinesin-like protein

Article Abstract:

The Drosophila no distributive disjunction (nod) gene encoding a kinesin-like protein helps in the DNA binding and meiotic chromosome location. The nod gene takes the chromosomes to the metaphase plate in female meiosis. The nonmotor domain of the nod protein binds directly to the DNA. In prometaphase, the nod proteins are present on the oocyte chromosome and the motor based chromosome-microtubule interactions take place at the chromosome arm.

Observations, Proteins, Chromosomes

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