The molecular basis of the type 1 glycogen storage diseases
Article Abstract:
Type 1 glycogen storage diseases are characterized by deficiencies in the glucose-6-phosphatase system, which catalyzes the last step in liver gluconeogenesis and glycogenolysis. The clinical variations of the disease are dependent on a specific component as detected by genetic studies. Kinetic analyses and clinical studies show that specific deficiency of the glucose-6-phosphatase enzyme, glucose-6-phosphate transport protein T1, a phosphate transport protein T2 or a microsomal glucose transport protein T3 would differentiate the clinical features, severity and probable gene therapy of these disorders.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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Molecular components of the mitotic spindle
Article Abstract:
Immunological probing, spindle isolate and mutational analysis indicate that the mitotic spindle apparatus is composed of numerous molecules that regulate and modulate microtubule dynamics. These include microtubule associated proteins (MAPs), calmodulin, calcium/calmodulin-dependent kinase, troponin-T, ankyrin, protein kinase inhibitors, membranous vesicles, tubulins and adenosine triphosphatase enzymes. By monoclonal antibody probing of cultured mammalian cells, a subcellular cell-cycle specific 95/105 kilodalton MAP was identified which stabilizes mitotic spindles during anaphase.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1992
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Odor receptor proteins recloned: molecular realities of olfactory discrimination in fish
Article Abstract:
The diversity of the catfish olfactory receptor proteins were assessed using polymerase chain reaction primers. Clones from the G-protein receptor family suggest the presence of olfactory receptor proteins in the catfish. Olfactory discrimination depends on receptor proteins while odorant discrimination depends on sensory neuron transmission to the brain. Randomness of receptor distribution suggest that selected tissues deal with a random distribution of the signal.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 1993
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