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The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Article Abstract:

The Activin receptor ALK4 and the orphan receptor ALK7 have been found to mediate signaling by Nodal proteins in vertebrate development. Investigation was done using gain- and loss-of-function experiments in Xenopus embryos directly compared to ALK4. Biochemical and functional evidence suggests that the orphan type I serine-threonine kinase receptor ALK7 functions as a receptor for Xenopus Nodal-related 1 and mouse Nodal.

Author: Brivanlou, Ali H., Reissmann, Eva, Jornvall, Henrik, Blokzijl, Andries, Andersson, Olov, Change, Chebei, Minchiotti, Gabriella, Persico, M. Graziella, Ibanez, Carlos F.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
Italy, Vertebrates, Cytochemistry, Cellular control mechanisms, Cell regulation

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Active repression of RAR signaling is required for head formation

Article Abstract:

Active repression of retinoic acid receptors (RAR) signaling has been found to be necessary for head formation. Specific reagents that reduce or augment RAR-mediated repression have been used to test the hypothesis that repression mediated through unliganded RARs might be important for anterior patterning.

Author: Downes, Michael, Blumberg, Bruce, Koide, Tetsuya, Chandraratna, Roshantha A.S., Umesono, Kazuhiko
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2001
Japan, Physiological aspects, Genetic aspects, Brain, Tretinoin, Developmental cytology, Head

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Synergistic interaction between Gdf1 and Nodal during anterior axis development

Article Abstract:

Combined genetic interaction between growth and differentiation factor 1 and nodal during the development of anterior axis is presented.

Author: Reissmann, Eva, Jornvall, Henrik, Andersson, Olov, Ibanez, Carlos F.
Publisher: Elsevier B.V.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
Science & research, Developmental genetics, Holoprosencephaly, Notochord

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Subjects list: Statistical Data Included, Research, United States, Usage, Sweden, Developmental biology, Xenopus
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