The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Article Abstract:

The Activin receptor ALK4 and the orphan receptor ALK7 have been found to mediate signaling by Nodal proteins in vertebrate development. Investigation was done using gain- and loss-of-function experiments in Xenopus embryos directly compared to ALK4. Biochemical and functional evidence suggests that the orphan type I serine-threonine kinase receptor ALK7 functions as a receptor for Xenopus Nodal-related 1 and mouse Nodal.

Italy, Vertebrates, Cytochemistry, Cellular control mechanisms, Cell regulation

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Active repression of RAR signaling is required for head formation

Article Abstract:

Active repression of retinoic acid receptors (RAR) signaling has been found to be necessary for head formation. Specific reagents that reduce or augment RAR-mediated repression have been used to test the hypothesis that repression mediated through unliganded RARs might be important for anterior patterning.

Japan, Physiological aspects, Genetic aspects, Brain, Tretinoin, Developmental cytology, Head

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Synergistic interaction between Gdf1 and Nodal during anterior axis development

Article Abstract:

Combined genetic interaction between growth and differentiation factor 1 and nodal during the development of anterior axis is presented.

Science & research, Developmental genetics, Holoprosencephaly, Notochord

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