The pncA gene from naturally pyrazinamide-resistant Mycobacterium avium encodes pyrazinamidase and confers pyrazinamide susceptibility to resistant M. tuberculosis complex organisms
Article Abstract:
A research on Mycobacterium avium and mycobacterium tuberculosis was conducted to determine their reaction to antituberculosis drug pyrazinamide. (PZA) Samples from the two mycobacteria were subjected to strains and DNA sequence analysis. Findings showed that both M. avium and M. tuberculosis have impermeable cell wall that deters antibiotics from penetrating the cell. However, M. avium's resistance to PZA was traced to its inability to convert PZA into bacterial pyrazinoic acid. The sequence analysis also provided that bacterial pyramidase has a high degree of homology with the M. tuberculosis enzyme.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1997
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Expression, secretion, and glycosylation of the 45- and 47 -kDa glycoprotein of mycobacterium tuberculosis in streptomyces lividans
Article Abstract:
The gene, encoding the 45- and 47 -kDa glycoprotein of mycobacterium tuberculosis was expressed in streptomyces lividans. It was found that the expression of genes for mycobacterial antigens in streptomyces lividans is useful for their functional role and molecular mechanisms of glycosylation in bacteria.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2004
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The PE-PGRS glycine-rich proteins of Mycobacterium tuberculosis: a new family of fibronectin-binding proteins?
Article Abstract:
This paper describes a new fibronectin-binding protein Rv1759c expressed in Mycobacterium tuberculosis. The protein belongs to the glycine-rich polymorphic GC-repetitive sequence family of proteins and is found in tuberculosis infection.
Publication Name: Microbiology
Subject: Biological sciences
ISSN: 1350-0872
Year: 1999
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