The proteasome: paradigm of a self-compartmentalizing protease
Article Abstract:
The structure of self-compartmentalizing proteases are characterized by mechanisms of action and protein degradations. The core structure is characterized by subunits arranged into four seven-membered rings and noncatalytic alpha and catalytic beta-type subunits having the same fold. Moreover, the assembly of the 20S proteasome is directly associated with the processing of the beta-type subunits. The alpha rings function as a template wherein the beta subunits assemble after the formation of a ring containing all of the seven alpha-type subunits.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Crystal and solution structures of an HslUV protease-chaperone complex
Article Abstract:
Research describes the crystal and solution structure of an heat shock locus gene products U and V complex of influenza virus. Data reveal that HsIU ATPase and HsIV protease of the complex bear 80% amino acid sequence homology to the Escherichia coli counterparts.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Cocrystal structure of a tRNA Psi55 pseudouridine synthase: nucleotide flipping by an RNA-modifying enzyme
Article Abstract:
The crystal structure of Psi synthase TruB bound to RNA shows that the enzyme recognizes T loop through shape complementarity. The enzyme accesses the uridyl substrate by flipping out the nucleotides, which disrupts the tRNA tertiary structure.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Fiber-degrading systems of different strains of the genus fibrobacter. Correlations between morphological, molecular biological, and physiological characteristics in clinical and nonclinical isolates of Acanthamoeba spp
- Abstracts: The influence of relative age on success and dropout in male soccer players. Effect of a change in selection year on success in male soccer players
- Abstracts: Perceptions and patterns of physical activity: a comparison of Mohawk/Cayuga and non-Native adolescents. Cardiac dynamics during upright cycle exercise in boys
- Abstracts: Interpreting skinfold sums. Use of absolute or relative typical error?. Seasonal ecology and nutritional status of women and children in a Tanzanian pastoral community
- Abstracts: Prevalence of overweight and obesity among Guarani-Mbya from Misiones, Argentina. Relationship between different subcutaneous adipose tissue layers, fat mass, and leptin in response to short-term energy restriction in obese girls