The repertoire of T cells shaped by a single MHC/peptide ligand

Article Abstract:

The transgene encoding class II major histocompatibility complex (II) proteins in mice without endogenous class II and invariant chain (Ii) was studied. Findings showed that in normal mice, a significant part of the positively selected CD4+ T cells in the thymus was clonally deleted because they reacted too strongly with the same MHC protein bound to other self-peptides. Results also suggested that T cell receptors may be even more biased in interacting with MHC molecules that formerly expected.

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H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

Article Abstract:

Mice with H2-Ma mutant genes were developed to study the importance of H2-M in loading peptides onto major histocompatibility complex (MHC) class II molecules. Cells from these mice did not produce complete protein antigens for MHC class II-restricted T cells and were hampered in producing exogenous peptides. The quantity of mature CD4+ T lymphocytes in the mutant mice were only 25 to 33% of the quantity in normal mice.

Antigens

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How the T cell repertoire becomes peptide and MHC specific

Article Abstract:

Study is conducted to show that the pool of T cells initially positively selected in the thymus contains many T cells that are very crossreactive for peptide and major histocompatability proteins (MHC)-restriction and peptide specificity of peripheral T cells. The results suggest that germline-encoded T cell receptor variable element has an inherent predisposition to react with features shared by all MHC proteins.

Science & research, Histocompatibility

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