Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency
Article Abstract:
Human and mouse TPIT, the T-box transcription factor, gene mutations have been found to cause early-onset pituitary adrenocorticotropin (ACTH) deficiency. Tpit-deficient mice serve as a model of isolated ACTH deficiency (IAD) that is much like that seen in human IAD patients with TPIT gene mutations, which have been shown to be associated with early-onset IAD, but not with juvenile forms.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
Canada, Netherlands, Germany, Turkey, Usage, Abnormalities, Genetic transcription, Transcription (Genetics), Cytochemistry, Mice, mutant strains, Mutant mice, Genetic disorders, Pituitary gland, ACTH, Corticotropin
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2003
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Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis
Article Abstract:
Using a study on mice, the influence of signaling activity of retinoic acid receptors on initial lung development is examined.
Publisher: Elsevier B.V.
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
United States, Genetic aspects, Lungs, Lung, Mice, Growth, Morphogenesis, House mouse, Tretinoin, Receptor antibodies, Company growth
Publication Name: Developmental Biology
Subject: Biological sciences
ISSN: 0012-1606
Year: 2006
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Subjects list: Research, France, Physiological aspects
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