The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

Article Abstract:

A study was conducted to analyze the crystal structure of the protein phosphatase 2A PR65/A subunit that functions as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Experimental results indicated that members of the protein family share a common architecture. Findings also showed that additional structural diversity could be produced by the sequence insertions between adjacent motifs.

Proteins, Phosphatases, Molecules

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Yeast prions and their prion-forming domain

Article Abstract:

This article discusses the nature of inheritance of stable phenotypic traits in yeast in a non-Mendelian fashion. Yeast prions replication mechanisms are discussed in the context of mammalian protein prions to point out that unlike the latter yeast prions are not infectious agents.

Usage, Genetic aspects, Prions, Yeast, Domain structure, Saccharomyces, Prions (Proteins), Yeast (Food product)

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The crystal structure of human eukayotic release factor eRF1-mechanism of stop codon recognition and peptidyl-tRNA hydrolysis

Article Abstract:

Results indicate that the GGQ sequence motiff on the release factor eRF1 triggers the hydrolytic activity of the peptidyl transferase complex. Data further show that substitutions of glycine residues in the motiff abolishes this activity of the eRF1.

Switzerland, Protein synthesis, Protein biosynthesis, Transfer RNA, Transferases, Crystals, Crystal structure

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