The unfolding tale of the unfolded protein response
Article Abstract:
This review unfolds the story of the unfolded protein response (UPR) process encountered with surface and secreted proteins in yeast and mammalian systems. The UPR begins when protein maturation, which involves protein folding, is interrupted at the endoplasm reticulum. Data indicate that three gene products can initiate the UPR in yeast and mammals.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
Article Abstract:
In the mammalian unfolded protein response process, two signaling systems meet at XBP1 molecule, whose mRNA is induced by ATF6 and spliced by IRE1 during endoplasm reticulum stress. This leads to the generation of transcription factor involved in the activation of mammalian unfolded protein response.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development
Article Abstract:
Results demonstrate that in C. elegans, ire-1 controls the splicing of endoplasm reticulum stress induced mRNA, which encodes the transcription factor XBP-1. Data indicate that splicing of xbp-1 mRNA is essential for activating the unfolded protein response.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: GcvA binding site 1 in the gcvTHP promoter of Escherichia coli is required for Gcva-mediated repression but not for Gcva-mediated activation
- Abstracts: Community analysis of the bacterial assemblages in the winter cover and pelagic layers of a high mountain lake by in situ hybridization
- Abstracts: Homogeneous expression of the P (sub)BAD promoter in Escherichia coli by constitutive expression of the low-affinity high-capacity AraE transporter
- Abstracts: A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death
- Abstracts: Homogeneous expression of the P (sub)BAD promoter in Escherichia coli by constitutive expression of the low-affinity high-capacity AraE transporter. part 2