The when and how of Src regulation
Article Abstract:
Src, a gene found widely distributed in the cells of the nervous system and blood platelets, can be activated and repressed by changes in the activities of specific kinases, phosphatases or allosteric effectors. The conserved region of this protein is divided into five sequence blocks. Interamolecular interactions involving the entire conserved region maintain the normal and repressed state of the molecule. Inhibition or activation of the gene is induced by changes in phosphorylation and mutations in many sites of the conserved regions of the protein. Src has an essential function in osteoclasis, a defect which results in osteopetrosis.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1993
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Rho family members: activators of MAP kinase cascades
Article Abstract:
Study analyzing the role of the Rho family members, Cdc42/G25K, Rac1, Rac2, RhoA, RhoB and RhoC in various biological processes finds a link from these GTPases to the nucleus and, for Cdc42 and Rac, to a mitogen activating protein kinase (MAPK) cascade. Rho family members also play vital roles in the regulation of the actin cytoskeleton. The observation that chronic activation of Cdc42, Rac and Rho by deregulated exchange factors induces malignant transformation as well as morphological changes suggests that these GTPases may regulate nuclear as well as cytoplasmic effects.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Lipoprotein receptors: signaling functions in the brain?
Article Abstract:
The low density lipoprotein receptor has been intensively studied. Its malfunction has been determined as the cause of atherosclerosis. It has been deemed important in transporting complexes of cholesterol, trigylycerides and specific apolipoproteins out of the plasma. Results from several studies indicate that lipoproteins will not support a critical regulatory function in the phenotype. Moreover, pathways regulated by family members of the receptor may be involved in neurodegenerative diseases.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1999
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