Abstracts

Biological sciences

Trait components provide tools to dissect the genetic susceptibility of migraine

Article Abstract:

An alternative strategy is introduced using trait components, that is, individual clinical symptoms of migraine in order to determine affection status in genomewide linkage analyses of migraine-affected families. The findings suggest that the use of symptom components of migraine instead of the end diagnosis provides a useful tool in stratifying the sample for genetic studies.

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Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly

Article Abstract:

Methylation at the promoter region of the AXIN1 gene, which is implicated in caudal duplication anomalies, and in twin and age-matched singleton controls, is examined using bisulfite sequencing. Methylation of the promoter region in peripheral blood mononucleated cells is variable among the individuals, including monozygotic (MZ) pairs.

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Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles

Article Abstract:

Several genome-wide analyses are conducted to study the DNA copy-number variations (CNVs) in the phenotypically concordant or discordant monozygotic twins. The twins are found to exhibit different CNV profiles, hence giving a better insight into their disease-predisposition loci.

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