Transformation of 2,2'-bimorphine to the novel compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine by Cylindrocarpon didymum
Article Abstract:
The biotransformation of biomorphine to two new morphine alkaloids by the fungus Cylindrocarpon didymum is discussed. If the fungal enzymes catalyzing these reactions can be expressed in E. coli, the morphine alkaloids could be produced industrially for therapeutic use.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 2001
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Transformations of morphine alkaloids by Pseudomonas putida M10
Article Abstract:
Pseudomonas (P.) putida M10 appears to be capable of converting morphine and oxymorphone (14- beta-hydroxydihydromorphinone) into morphine alkaloids which may be useful in the production of partially synthetic opiates. P. putida grown in the presence of morphine and oxymorphone produced hydromorphone (dihydromorphinone), 14-beta-hydroxymorphine, 14-beta- hydroxymorphinone, the pain-killer dihydromorphine, and oxymorphol (14-beta- hydroxydihydromorphine).
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 1995
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Oxidation of morphine to 2,2'-bimorphine by Cylindrocarpon didymum
Article Abstract:
A study was conducted to analyze the oxidation of morphine to 2,2'-bimorphine by Cylindrocarpon didymum 311186. The Bruker AM-400 spectrometer was utilized to carry out 1H nuclear magnetic resonance spectroscopy experiments. Experimental results indicated that C. didymum supported activity with the morphine analogs hydromorphine, 6-acetylmorphine, and dihydromorphine.
Publication Name: Applied and Environmental Microbiology
Subject: Biological sciences
ISSN: 0099-2240
Year: 1998
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