Transformation of 2,2'-bimorphine to the novel compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine by Cylindrocarpon didymum

Article Abstract:

The biotransformation of biomorphine to two new morphine alkaloids by the fungus Cylindrocarpon didymum is discussed. If the fungal enzymes catalyzing these reactions can be expressed in E. coli, the morphine alkaloids could be produced industrially for therapeutic use.

Industrial microorganisms

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Transformations of morphine alkaloids by Pseudomonas putida M10

Article Abstract:

Pseudomonas (P.) putida M10 appears to be capable of converting morphine and oxymorphone (14- beta-hydroxydihydromorphinone) into morphine alkaloids which may be useful in the production of partially synthetic opiates. P. putida grown in the presence of morphine and oxymorphone produced hydromorphone (dihydromorphinone), 14-beta-hydroxymorphine, 14-beta- hydroxymorphinone, the pain-killer dihydromorphine, and oxymorphol (14-beta- hydroxydihydromorphine).

Observations, Microbial metabolism, Pseudomonas putida

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Oxidation of morphine to 2,2'-bimorphine by Cylindrocarpon didymum

Article Abstract:

A study was conducted to analyze the oxidation of morphine to 2,2'-bimorphine by Cylindrocarpon didymum 311186. The Bruker AM-400 spectrometer was utilized to carry out 1H nuclear magnetic resonance spectroscopy experiments. Experimental results indicated that C. didymum supported activity with the morphine analogs hydromorphine, 6-acetylmorphine, and dihydromorphine.

Oxidation-reduction reaction, Oxidation-reduction reactions, Alkaloids

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