Translational resistance of late alphavirus mRNA to eIF2(alpha) phosphorylation: A strategy to overcome the antiviral effect of protein kinase PKR
Article Abstract:
Protein kinase (PKR) is highly activated following infection with alphaviruses Sindbis (SV) and Semliki Forest virus (SFV), leading to the almost complete phosphorylation of enkaryotic initiation factor 2(alpha) [eIF2(alpha)]. Findings show the existence of an alternative way to locate the ribosomes on the initiation codon of mRNA that is exploited by a family of viruses to counteract the antiviral effect of PKR.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Default neural induction: Neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation
Article Abstract:
Xenopus embryonic ectodermal cells dissociated for three or more hours differentiate into neural tissue instead of adopting their normal epidermal fate. The observations reveal that cell dissociation induces a sustained activation of the Ras/ MAPK (mitogen-activated protein kinasse) pathway, which causes the phosphorylation of Smad1 at sites that inhibit the activity of this transcription factor.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Quality control of gene expression: A stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay
Article Abstract:
A stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay is presented. SMG7 is one of the components of the surveillance complex that couples changes in the phosphorylation state of UPFI with mRNA degradation.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Genetic structure of a Spodoptera frugiperda nucleopolyhedrovirus population: high prevalence of deletion genotypes
- Abstracts: Localization of white spotting locus in boxer dogs on CFA20 by genome-wide linkage analysis with 1500 SNPs. Canine DNA Subjected to Whole Genome Amplification is Suitable for a Wide Range of Molecular Applications
- Abstracts: Complementation rescue of Pdx1 null phenotype demonstrates distinct roles of proximal and distal cis-regulatory sequences in pancreatic and duodenal expression
- Abstracts: Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates
- Abstracts: The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes. A pathway in quiescent cells that controls p27(super Kip1) stability, subcellular localization, and tumor suppression