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Type 2 diabetes TCF7L2 risk genotypes alter birth weight: A study of 24, 053 individuals

Article Abstract:

A hypothesis that fetal TCF7L2 type-2 diabetes predisposing genotypes at rs7903146 and rs12255372 would be associated with reduced birth weight was investigated in individuals from six population-based studies. The first type-2 diabetes susceptibility allele was identified and found to be reproducibly associated with birth weight and common gene variants were found to substantially influence normal birth weight variation.

Author: Smith, George Davey, Hattersley, Andrew T., Bennett, Amanda, Frayling, Timothy M., Power, Chris, Ben-Shlomo, Yoav, Pembrey, Marcus E., Freathy, Rachel M., Weedon, Micahel N., Hypponen, Elina, Strachan, David P., Jarvelin, Marjo-Riitta, McCarthy, Mark I., Relton, Caroline L., Knight, Beatrice, Shields, Beverley, Parnell, Kirstie S., Groves, Christopher J., Ring, Susan M.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Genetic aspects, Type 2 diabetes, Genotype, Genotypes

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A common haplotype of the glucokinase gene alters fasting glucose and birth weight: Association in six studies and population-genetics analyses

Article Abstract:

The role of variation of glucokinase (GCK) in the determination of fasting glucose and birth weight is examined using a tagging single-nucleotide polymorphism (tSNP) approach. A comprehensive analysis of common variation of the glucokinase gene has indicated that this is the first gene to be reproducibly associated with fasting glucose and fetal growth.

Author: Smith, George Davey, Ferrucci, Luigi, Melzer, David, Hattersley, Andrew T., Ring, Susan, Corsi, Anna Maria, Weedon, Michael N., Clark, Vanessa J., Yudong Qian, Ben-Shlomo, Yoav, Timpson, Nicholas, Ebrahim, Shah, Lawlor, Debbie A., Pembrey, Marcus E., Wilkin, Terry J., Voss, Linda D., Jeffrey, Alison N., Metcalf, Brad, Murray, Anna, Knight, Bridget, Shields, Bev, Di Rienzo, Anna, Frayling, Tim M.
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2006
Human population genetics, Fasting, Glucokinase

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Permanent neonatal diabetes caused by dominant, recessive, or compound heterozygous SUR1 mutations with opposite functional effects

Article Abstract:

The article describes about the active mutations that are heterozygous in the KCNJ11 gene encodes pore-forming Kir6.2 subunits of the pancreatic beta cell [K.sub.ATP] channel are the most common cause of permanent neonatal diabetes (PNDM).

Author: Hattersley, Andrew T., Ashcroft, Frances M., Carson, Dennis J., Proks, Peter, Shield, Julian P.H., Flanagan, Sarah E., Ellard, Sian, Parrish, Andrew, Edghill, Emma L., Girard, Christophe A., Patch, Ann-Marie, Harries, Lorna W., Mackey, Deborah J.G., Shimomura, Kenju, Haberland, Holger
Publisher: University of Chicago Press
Publication Name: American Journal of Human Genetics
Subject: Biological sciences
ISSN: 0002-9297
Year: 2007
Causes of, Gene mutations, Gene mutation, Juvenile diabetes, Genetic code, Pancreatic beta cells, Diabetes in children, Clinical report

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Subjects list: Research, Birth weight, Birth size, Report
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