What can Drosophila tell us about serpins, thrombosis and dementia?
Article Abstract:
This article discusses the validity of Drosophila model for human genetic diseases. Research shows that mutations in the fruit-fly leading to necrotic disease phenotype mirror human diseases ranging from thrombosis to dementia. Data reveal that these diseases result from mutations affecting conformational instability in serpin protease inhibitors.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2004
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Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis
Article Abstract:
Mutational activation of ErbB family receptor tyrosine kinases that affect enzymatic activity, substrate specificity and coupling was analyzed. ErbB receptor mutations that affect ligand binding and causing constitutive receptor phosphorylation and signaling as a result of constitutive receptor dimerization were also discussed.
Publication Name: BioEssays
Subject: Biological sciences
ISSN: 0265-9247
Year: 2007
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The rho GTPase and a putative rhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation
Article Abstract:
Rho GTPases control actin rearrangements needed for several cell shape changes in developing embryos. The DRhoGEF2 gene, encoding a predicted Rho-specific guanine nucleotide exchange factor, has been identified in Drosophila. Gastrulation does not occur when embryos lack DRhoGEF2, because of defective cell shape changes.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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