XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly

Article Abstract:

A protein responsible for regulating the structures of microtubules involved in mitosis was identified suing antibody staining. The protein is produced by a gene derived from the cDNA of Xenopus. The absence of this protein during mitosis causes the formation of microtubules that are longer than is necessary for mitosis, but this effect can be reversed by adding XKCM1 to the cell, pointing to its function in depolymerizing microtubules. In addition, its structure has been identified as similar to the kinesin family of proteins.

Kinesin

---

Kinetochore microtubule dynamics and attachment stability are regulated by Hec1

Article Abstract:

A study reports that Ndc80/Hec1 functions in regulating kineto-chore microtubule plus-end dynamics and attachment stability. The N terminus of Hec1 is phosphorylated by Aurora B kinase in vitro, and cells expressing N-terminal nonphosphorylatable mutants of Hec1 display an increase in merotelic attachments, hyper-stretching of centromeres, and errors in chromosome segregation, all of which reveal a key role for the Hec1 N terminus in controlling dynamic behavior of kinetochore microtubules.

Cell cycle

---

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

Article Abstract:

The conserved KNL-1/Mis12 complex/Ndc80 complex (KMN) network, which is essential for kinetochore-microtubule interactions, is examined. The results demonstrate that the Ndc80 complex is a conserved Aurora kinase target and suggest that reduction in its microtubule-binding affinity after phosphorylation of the Ndc80 subunit might contribute to Aurora kinase-dependent elimination of incorrect kinetochore-microtubule attachments in vivo.

Binding sites (Biochemistry), Active sites (Biochemistry), Chromosomes

Similar abstracts:

• Abstracts: Wdr5, a WD-40 protein, regulates osteoblast differentiation during embryonic bone development. Sohlh1 is essential for spermatogonial differentiation
• Abstracts: The BRCA1/BARD1 heterodimer modulates Ran-development mitotic spindle assembly. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
• Abstracts: The C terminus of the L-type voltage-gated calcium channel [Ca.sub.v]1.2 encodes a transcription factor. Re-evaluating cell-cycle regulation by E2Fs
• Abstracts: PLA2G6 mutation underlines infantile neuroaxonal dystrophy. Lethal contractural syndrome type 3 (LCCS3) is caused by a mutation in PIP5K1C, which encodes [PIPKI.sub.[gamma]] of the phophatidylinsitol pathway
• Abstracts: Two-dimensional crystallography of TFIIB- and IIE-RNA polymerase II complexes: implications for start site selection and initiation complex formation

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.