XRCC3 promotes homology-directed repair of DNA damage in mammalian cells
Article Abstract:
Homology-directed repair of DNA damage in mammalian cells is discussed. This repair is now known to be a major factor in maintenance of genomic integrity in these cells and the much-conserved strand transferase, Rad51, is likely to be critical in the process. XRCC3 has limited sequence similarity to Rad51, with which it interacts. It has been shown through use of novel fluorescence-based testing that accurate homology-directed DNA double-strand break repair is cut 25-fold in a hamster cell line deficient in XRCC3. It can be restored to wild levels with XRCC3 expression.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
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X-inactivation by chromosomal pairing events
Article Abstract:
New findings suggest that X-inactivation involves transvection and takes advantage of heterochromatin association. Topics discussed include medical implications, chromosomal pairing events in X-inactivation, chromatin's role in dosage compensation, similarities between autosomal imprinting, X-inactivation and random vs imprinted inactivation and whether the mechanism is shared.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 1999
User Contributions:
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