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Biological sciences

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Functional genomics identifies monopolin: A kinetochore protein required for segregation of homologs during meiosis I

Article Abstract:

Results demonstrate that chromosome behavior in meiosis is independently influenced by the kinetochore associated Monopolin protein that mediates monopolar attachement and Rec8, which is involved in maintaining cohesion between sister centromeres in Saccharomyces cerevisiae.

United States, Chromosome replication, Cell division, Cell research, Cytological research

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Yeast Cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication

Article Abstract:

Studies have identified a protein required for cohesion but is not a Cohesin subunit. This protein, Eco1p(Ctf7), was found during experiments searching for mutants that generate separate sister centromeres. While Eco1p(Ctf7) is needed for cohesion establishment during DNA replication, it is not required for cohesion maintenance during the G2 and M phases.

DNA, Cohesion, Cohesion (Materials)

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A central role for cohesins in sister chromatid cohesion, formation of axial elements, and recombination during yeast meiosis

Article Abstract:

A study has been conducted to investigate the behavior of two cohesin subunits known to important for sister chromatid cohesion processes during mitosis and meiosis. Findings indicate that Scc1p is expressed at extremely low levels in meiotic cells, while the scc1-73 allele, considered to be conditionally lethal in mitosis, exerts a modest influence on spore formation and viability. A meiotic cohesin that binds sister chromatids together is also required for repair of strand exchange between homologs.

Genetic recombination, Yeast, Yeast (Food product)

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