cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
Article Abstract:
Molecular biological techniques were performed to study the factors affecting cell growth, differentiation and gene expression. The results showed that cAMP can activate the transcription factor Elk-1 and induce neuronal differentiation of PC12 cultured cells through its activation of the MAP kinase. Such activation of the MAP kinase was observed to be an extracellular signal-regulated kinases (ERK)-dependent but Ras-independent signal transduction pathway.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
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Novel disease resistance specificities result from sequence exchange between tandemly repeated genes at the Cf-4/9 locus of tomato
Article Abstract:
The Cf genes in tomatoes are responsible for resistance against Cladosporidium fulvum. There are several copies of this gene and 11 of these copies were analyzed for amino acid composition. Results revealed seven hypervariable amino acid residues in the leucine-rich domain. The predicted structure of the protein exposes these residues to the solvent. Further analysis of this domain reveals selection for sequence diversification.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1997
User Contributions:
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