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Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells

Article Abstract:

A promising therapeutic approach for a number of diseases can be found in the adoptive transfer of antigen-specific cytotoxic T lymphocytes (CTLs). Stable artificial antigen-presenting cells (AAPCs) that can be used to stimulate T cells in any patient of a given human leukocyte (HLA) type are estabblished, thuis overcoming the difficulty in generating specific CTLs.

Author: Latouche, Jean-Baptiste, Sadelain, Michel
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2000
Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Biological Product (except Diagnostic) Manufacturing, Surgical and Medical Instrument Manufacturing, Surgical and medical instruments, Biological products exc. diagnostic, Cancer & Cell R&D, Source Leukocytes, Antigen Detection Tests, Cancer research, Medical testing products, Immunologic tests, Blood products

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The ABCs of artificial antigen presentation

Article Abstract:

Artificial antigen presentation helps in increasing the speed of establishment of therapeutic cellular immunity and the artificial antigen-presenting cells (AAPCs) stimulate the expansion of the optimal therapeutic features of T cells before therapeutic infusion. Artificial antigen-presenting systems consist of cell-based and acellular technologies, which focus on potency, antigen specificity and biosafety as measures for possible clinical use.

Author: Latouche, Jean-Baptiste, Sadelain, Michel, Riviere, Isabelle, Kim, Jiyun V
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
Analysis, T cells, Cell research, Cytological research, Antigen-antibody reactions

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A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference

Article Abstract:

A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference is presented. The strategy demonstrates the feasibility and therapeutic potential of coregulating transgene expression and RNA interference in hematopoietic stem cells.

Author: Sadelain, Michel, Riviere, Isabelle, Ping Zhu, Samakoglu, Selda, Di Marzo, Rosalba, Maggio, Aurelio, Tisdale, John F., Budak-Alpdogan, Tulin, Usachenko, Yelena, Acuto, Santina
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
Gene expression, Hematopoietic stem cells, RNA interference

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Subjects list: United States, Research
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