Breaking the barriers to global gene delivery

Article Abstract:

The remarkable global muscular transduction in rodent models is demonstrated by exploiting the natural diversity present in viral capsids. Efficient transduction is achieved by one serotype of adeno-associated virus (AAV), AAV8, suggesting that the barriers to global muscular gene delivery are surmountable by careful selection of the viral serotype.

Serotonin, Serotonin receptors

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Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart

Article Abstract:

Adeno-asssociated virus (AAV) 8 is the most efficient vector for crossing the blood vessels barrier to attain systemic gene transfer in both skeletal and cardiac muscles of mice and hamsters. Serotypes such as AAV1 and AAV6, which demonstrate robust infection in skeletal muscle cells, were less effective in crossing the blood vessel barrier.

Muscles, Skeletal muscle

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