Creation and implications of a phenome-genome network

Article Abstract:

A phenome-genome network model extracts contextual concepts from the sample annotations in Gene Expression Omnibus (GEO), represents the concepts using the Unified Medical Language System (UMLS), unifies the gene expression measurements across data sets using NCBI gene identifiers and finally relates the gene expression measurements to the contextual concepts. Novel genes related to concepts such as aging are identified using the model.

Aging, Genetic research, Aging (Biology)

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Substrate-induced gene-expression screening of environmental metagenome libraries for isolation of catabolic genes

Article Abstract:

The utility of substrate-induced gene expression screening (SIGEX) scheme is demonstrated for the isolation of novel catabolic genes from a metagenome library. SIGEX can be used as an approach to facilitate access to novel biocatalysts in natural genetic resources.

Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Microorganisms, Nucleotides

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