Dimethyl sulfoxide to vorinostat: Development of this histone deacetylase inhibitor as an anticancer drug

Article Abstract:

The discovery and development of suberoylanilide hydroxamic acid (SAHA, vorinostat (Zolinza)), which is a histone deacetylase inhibitor, and the results of SAHA trials in cancer patients are described. The U.S. Food and Drug Administration (FDA) has approved a new drug application for vorinostat for treatment of cutaneous T-cell lymphoma.

All Other Basic Organic Chemical Manufacturing, Anticancer Drugs, Industrial Organic Chemicals, Chemotherapeutic Drugs, Dimethyl Sulfoxide, Antineoplastic agents, Antimitotic agents, Zolinza (Medication)

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Exploiting lymphatic transport and complement activation in nanoparticle vaccines

Article Abstract:

The utility of nanoparticles as a vaccine platform is examined by targeting lymph node-residing dendritic cells through interstitial flow and activating these cells by is situ complement activation.

Drug Delivery Systems, Drugs, Dendrites, Lymph nodes, Antigens, Nanoparticles

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Arthritis: the aging population of developed countries are likely to present a growing market for arthritis therapies

Article Abstract:

Arthritis has many form. It is a chronic mulltifactorial disease caused when the immune system attacks and begins degrading the body's joints.

Antiarthritic Analgesic Preps, Brief Article, Antiarthritic agents

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