Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Article Abstract:

The effects of bevacizumab on tumor physiology, systemic response and tumor response are evaluated. It is shown that a single infusion of the vascular endothelial growth factor (VEGF)-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, circulating endothelial and progenitor cells and increases the fraction of vessels with pericyte coverage in rectal carcinoma patients.

Health aspects, Care and treatment, Colorectal cancer

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Moving in and out with quantum dots

Article Abstract:

An optical biopsy is performed by clinicans, zooming in from the whole body to the tissue containing the suspected tumor and proceeding to look for telltale signs at the cellular and sub-cellular levels. Application of these nanoparticulate beacons to cancer has the potential to provide information unique to each length scale, from the whole body to molecular targets.

Methods, Usage, Diagnosis, Causes of, Quantum optics, Tumour removal, Tumor removal

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Engineering vascularized tissue

Article Abstract:

The vascularization of engineered tissue constructs before transplantation helps in creating functional blood vessels to supply cells with oxygen and nutrients and to remove waste products. It is demonstrated that prevascularization improves the in vivo performance of the tissue constructs in three different models in mice.

Blood vessels, Tissue engineering

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