Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
Article Abstract:
The effects of bevacizumab on tumor physiology, systemic response and tumor response are evaluated. It is shown that a single infusion of the vascular endothelial growth factor (VEGF)-specific antibody bevacizumab decreases tumor perfusion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, circulating endothelial and progenitor cells and increases the fraction of vessels with pericyte coverage in rectal carcinoma patients.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Moving in and out with quantum dots
Article Abstract:
An optical biopsy is performed by clinicans, zooming in from the whole body to the tissue containing the suspected tumor and proceeding to look for telltale signs at the cellular and sub-cellular levels. Application of these nanoparticulate beacons to cancer has the potential to provide information unique to each length scale, from the whole body to molecular targets.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
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Engineering vascularized tissue
Article Abstract:
The vascularization of engineered tissue constructs before transplantation helps in creating functional blood vessels to supply cells with oxygen and nutrients and to remove waste products. It is demonstrated that prevascularization improves the in vivo performance of the tissue constructs in three different models in mice.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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