Gene knockdown by large circular antisense for high-throughput functional genomics

Article Abstract:

Single-stranded genomic DNA of recombinant M13 phages was tested as an antisense molecule and its usefulness in high-throughput functional genomics is examined. The results shows that an antisense sequence as a part of single-stranded LC-genomic DNA of recombinant M13 phages exhibit effective antisense activity.

Observations, Nucleotide sequence, Base sequence

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Human disease classification in the postgenomic era: a complex systems approach to human pathobiology

Article Abstract:

A new approach to classifying human disease using conventional reductionism and incorporating the non-reductionist approach of systems biomedicine is explored. The approach aims to eliminate the lack of specificity in defining disease unequivocally.

Methods, Medical tests, Genotype, Genotypes, Phenotype, Phenotypes

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Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin

Article Abstract:

The characteristic structural topology of avian influenza A viruses' hemagglutinin and its adaptation from avian-like [alpha]2-3 to human-like [alpha]2-6 sialylated glycans to infect humans is described.

Composition, Protein binding, Agglutinins, Structure, Avian influenza viruses

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