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Imaging the pharmacodynamics of HER2 degradation in response to Hsp90 inhibitors

Article Abstract:

The development of therapeutic inhibitors of key signaling pathways is hampered by the inability to assess the effect of a particular drug on its target in the patient. An F(ab')(sub 2) fragment of the anti-HER2 antibody Herceptin with (Super 68)Ga, a position emitter, which allows the sequential positron-emission tomographic imaging of Her2 expression, is labeled.

Author: Akhurst, Timothy, Larson, Steven M., Smith-Jones, Peter M., Solit, David B., Rosen, Neal
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2004
Usage, Tomography, Schonlein-Henoch purpura, Allergic purpura, Trastuzumab

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Serial in vivo imaging of the targeted migration of human HSV-TK-transduced antigen-specific lymphocytes

Article Abstract:

A study is conducted to demonstrate that Epstein-Barr virus (EBV) specific T cells transduced with vectors encoding herpes simplex virus-1 thymidine kinase (HSV-TK) selectively accumulate radiolabeled FIAU. New technologies are needed to characterize the migration, survival and function of antigen-specific T cells in vivo.

Author: Sadelain, Michel, May, Chad, Doubrovin, Mikhail, Balatoni, Julius, Finn, Ronald, Ivanova, Anna, O'Reilly, Richard J., Riviere, Isabelle, Koehne, Guenther, Doubrovina, Ekaterina, Zanzonico, Pat, Gallardo, Humilidad F., Teruya-Feldstein, Julie, Heller, Glen, Ponomarev, Vladimir, Ruan, Shutian, Blasberg, Ronald G., Bornmann, William, Larson, Steven M., Tjuvajev, Juri G. Gelovani
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
United States, Case studies, T cells, Herpes simplex virus, Epstein-Barr virus

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Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo

Article Abstract:

The development of a targeted antisense approach to inhibit the dominant negative transcription factor ld1 in the tumor endothelium of living animals is reported.

Author: Benezra, Robert, Manova, Katia, Ponomarev, Vladimir, Solit, David B., Rosen, Neal, Cartegni, Luca, Henke, Erik, Perk, Jonathan, Vider, Jelena, de Candia, Paola, Chin, Yvette
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2008
DNA binding proteins, Antisense DNA, DNA microarrays, Tumor markers, Tumour markers

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