Immunostimulatory DNA-based vaccines induce cytotoxic lymphocyte activity by a T-helper cell-independent mechanism

Article Abstract:

Immunostimulatory DNA (ISS) sequences containing unmethylated CpG dinucleotides are the basis of vaccines that induce activity in antigen-specific cytotoxic lymphocytes and a response in the Th1 immune system.

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a T-cell-selective interleukin 2 mutein exhibits potent antitumor activity and is well tolerated in vivo

Article Abstract:

Human interleukin 2 is an approved therapeutic for advanced-stage metastatic cancer. Because of severe system toxicity its use is restricted. Toxicity may be mediated by natural killer cells.

Product standards, safety, & recalls, Interleukin, Interleukins

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Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity

Article Abstract:

Researchers from the National Cancer Institute, MD, converted a tumor antigen into vaccine by attaching a chemokine to its lymphona lg variable regions.

Brief Article

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