The use of single-nucleotide polymorphism maps in pharmacogenomics

Article Abstract:

Variations of single-nucleotide polymorphisms (SNPs) in individual DNA are being revealed and stored into large SNP databases to enable more research on pharmacogenomics.

Author: McCarthy, Jeanette J, Hilfiker, Rolf

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A DNA computing readout operation based on structure-specific cleavage

Article Abstract:

The authors describe a structure specific cleavage-based readout strategy for surface-based DNA computing.The readout is simple, accurate and compatible with multi-word DNA computing.

Author: Wang, Liman et al
Biochemistry, Research and Development in the Physical, Engineering, and Life Sciences, Illustration

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Polymorphism identification and quantitative detection of genomic DNA by invasive cleavage of oligonucleotide probes

Article Abstract:

Researchers from Third Wave Technologies used flap endonucleases isolated from archaea to demonstrate its cleavage when its oligonucleotides attaches itself to a target DNA strand.

Author: Lyamichev, Victor, Mast, Andrea L., Hall, Jeff G., Prudent, James R., Kaiser, Michael W., Takova, Tsetska, Kwiatkowski, Robert W., Sander, Tamara J., De Arruda, Monika, Arco, David A., Neri, Bruce P., Brow, Mary Ann D.
Brief Article, Third Wave Technologies Inc.

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Subjects list: United States, DNA probes
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