Differential effects of cholesterol, ergosterol and lanosterol on a dipalmitoyl phosphatidylcholine membrane: A molecular dynamics simulation study

Article Abstract:

Molecular dynamics simulation study is used to investigate the differential effects of three closely-related sterols, cholesterol, ergosterol and lanosterol on the dipalmitoyl phosphatidylcholine membrane. The findings prove that ergosterol is the most efficient of all three, as it helps in promoting the liquid-ordered phase, as well as the lipid domain formation in the membrane.

Cell membranes, Molecular dynamics, Sterols, Structure, Report

---

Decomposing complex cooperative ligand binding into simple components: connections between microscopic and macroscopic models

Article Abstract:

The framework of the decoupled sites representation (DSR), previously developed in the context of pH titration, is extended to include cooperative ligand binding as well as multiple conformations and multiple ligands. It cam be used to elucidate the connection between the experimentally observed binding curves and parameters of underlying microscopic models.Z

Comparative analysis, Observations, Ligand binding (Biochemistry), Chemical microscopy

---

Relations between protonation constants and titration curves in polyprotic acids: A critical view

Article Abstract:

The titration curves of individual sites in polyprotic acids can be irregular and do not need to show a sigmoidal shape. For irregular titration curves, the pH at which protonation (pK(sub 1/2) value) takes place is 0.5, or the inflection of titration curves of individual sites or of the total titration curve cannot be identified with the pKa value.

Hydrogen-ion concentration, pH, Organic acids, Acetohydroxamic acid

Similar abstracts:

• Abstracts: On the atomistic mechanisms of alkane (methane-pentane) separation by distillation: A molecular dynamics study
• Abstracts: Effect of cholesterol on the properties of phospholipid membranes. 4. Interatomic voids. Effect of cholesterol on the properties of phospholipid membranes. 2. free energy profile of small molecules
• Abstracts: NMR study of strontium binding by a micaceous mineral. Modeling the synthesis of amorphous Si3B3N7 via a sequence of dynamically well-separated steps
• Abstracts: Influence of the electrical double layer in electrowetting. Dibenzosuberenylidene-ended fluorophores: Rapid and efficient synthesis, characterization, and aggregation-induced emissions

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.