Hydrophobic distal pocket affects NO-heme geminate recombination dynamics in dehaloperoxidase and H64V myoglobin
Article Abstract:
The recombination dynamics of NO with dehaloperoxidase (DHP) from Amphitrite ornata following photolysis are measured by femtosecond time-resolved absorption spectroscopy. The analysis of ligand recombination in photolyzed DHP-NO and H64V Mb-NO has provided evidence for the vital role of the distal histidine in stabilizing the NO ligand in the docking site, which provides a barrier to recombination that is modulated by protein dynamics and temperature.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2006
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Ultrafast heme dynamics in ferrous versus ferric cyctochrome c studied by time-resolved resonance Raman and transient absorption spectroscopy
Article Abstract:
A comprehensive study on horse heart cytochrome c (Cyt c) by subpicosecond time-resolved resonance Raman and femtosecond transient adsorption spectroscopy is performed. It is found that in ferric Cyt c, in contrast to ferrous Cyt c, the photodissociation of an internal ligand does not take place, and relaxation dynamics is dominated by vibrational cooling in the ground electronic state of heme.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
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