Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide

Article Abstract:

The effects of dimethyl sulfoxide (DMSO) on a phospholipid membrane in the liquid-crystalline phase are examined by using the atomic-scale molecular dynamics (MD) simulations with realistic potentials for the modeled molecules. The results have shown that the choice of DMSO concentration for the given application is critical because the concentration has defined the specific mode of the solvent's action.

Cell membranes, Structure

---

Ion transport through chemically induced pores in protein-free phospholipid membranes

Article Abstract:

Molecular dynamics simulations are carried out using realistic atomic-scale models in order to observe diffusive transmembrane ionic leakage through transient water pores induced by dimethyl sulfoxide (DMSO). The results have shown that the small amphiphilic solute DMSO is able to induce transient defects in membranes and also promote a subsequent diffusive pore-mediated transport of salt ions.

Observations, Electron transport, Chemical properties

---

Molecular mechanism for lipid flip-flops

Article Abstract:

The molecular mechanism of pore-mediated transmembrane lipid translocation (flip-flop) obtained from atomistic molecular dynamics simulations is described. The results have shown that the exposure of lipid membranes to electric field pulses have reduced the time required for lipid flip-flops.

Biological transport

Similar abstracts:

• Abstracts: Atomic detail investigation of the structure and dynamics of DNA-RNA hybrids: a molecular dynamics study. Impact on pyrophosphate and O-ethyl-substituted pyrophosphate groups on DNA structure
• Abstracts: Vibrational spectroscopy and dynamics of azide ion in ionic liquid and dimethyl sulfoxide water mixtures. Surfactant charge effects on the location, vibrational spectra, and relaxation dynamics of cyanoferrates in reverse micelles
• Abstracts: Influences of structural properties on stability of fullerenols. Photochemical and photophysical properties of three carbon-bridged fullerene dimers: [C.sub.121] (I, II, III)
• Abstracts: Host-guest chemistry and light driven molecular lock of Ru[(bpy).sub.3]-viologen with cucurbit[7-8]urils. Femtosecond pump/probe spectroscopy of CO on Ru[1010] from experimental and theoretical perspectives
• Abstracts: Laser-light-scattering study of internal motions of polymer chains grafted on spherical latex particles. Observation of kinetic and structural scalings during slow coalescence of nanobubbles in an aqueous solution

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.