PEO-PPO block copolymer vectors do not interact directly with DNA but with lipid membranes
Article Abstract:
Small angle neutron (SANS) and light scattering is used for studying the interaction between fragments of double stranded deoxyribonucleic acid (DNA) and a synthetic triblock [poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)] amphiphilic polymer (L64), a potential vector for gene therapy. The electrical measurements on black lipid membranes have shown that the major effect of L64 as a vector is to permeabilize the cell's membrane.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2007
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Molecular dynamics simulation of ss-DNA translocation between copper nanoelectrodes incorporating electrode charge dynamics
Article Abstract:
Molecular dynamics simulations are used for studying the translocation of single-stranded (ss)-DNA through the nanoscale gap between the nanoscale electrodes of a proposed genomic sequencing device. The studies have shown that the electrode charge dynamics (ECD) potential is a better descriptor of the metal/nonmetal electrostatic interactions when compared to the universal force field (UFF).
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2008
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The puzzle of contrast inversion in DNA STM imaging
Article Abstract:
The phenomenon of contrast inversion in scanning tunneling microscope (STM) imaging of DNA, both due to a controlled change in the imaging parameters or spontaneously induced is demonstrated. A model is formulated which describes the phenomenon via indirect tunneling through virtual states in the vacuum between the STM tip and the DNA molecule.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 2005
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