PEO-PPO block copolymer vectors do not interact directly with DNA but with lipid membranes

Article Abstract:

Small angle neutron (SANS) and light scattering is used for studying the interaction between fragments of double stranded deoxyribonucleic acid (DNA) and a synthetic triblock [poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)] amphiphilic polymer (L64), a potential vector for gene therapy. The electrical measurements on black lipid membranes have shown that the major effect of L64 as a vector is to permeabilize the cell's membrane.

Lipid membranes, Light scattering

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Molecular dynamics simulation of ss-DNA translocation between copper nanoelectrodes incorporating electrode charge dynamics

Article Abstract:

Molecular dynamics simulations are used for studying the translocation of single-stranded (ss)-DNA through the nanoscale gap between the nanoscale electrodes of a proposed genomic sequencing device. The studies have shown that the electrode charge dynamics (ECD) potential is a better descriptor of the metal/nonmetal electrostatic interactions when compared to the universal force field (UFF).

Primary copper, Secondary nonferrous metals, Molecular dynamics, Copper, Electrodes, Mechanical properties, Copper (Metal), Electrostatic interactions

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The puzzle of contrast inversion in DNA STM imaging

Article Abstract:

The phenomenon of contrast inversion in scanning tunneling microscope (STM) imaging of DNA, both due to a controlled change in the imaging parameters or spontaneously induced is demonstrated. A model is formulated which describes the phenomenon via indirect tunneling through virtual states in the vacuum between the STM tip and the DNA molecule.

Israel, Usage, Scanning tunneling microscopy, DNA replication

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