A critical appraisal of the evolution of N-nitrosoureas as anticancer drugs
Article Abstract:
The most recent generation, Fourth, of N-nitrosourea analogs with anticancer activities include amino acid and carbohydrate analogs with aminoxyl (nitroxyl) moieties, and conjugates such as steroid-amino acids. The First Generation of N-nitrosourea analogs with anticancer activities consist of heterocyclic, aromatic, alicyclic and lipophilic aliphatic analogs. The Second Generation comprises hydroxyalicyclic and hydroxyalkyl analogs, while the Third Generation comprises analogs containing carrier-groups such as nucleotides and peptides. The anticancer activity of N-nitrosourea drugs will be affected by carcinogenicity, toxicology, pharmacology and metabolism.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Electron transfer at semiconductor electrode-liquid electrolyte interfaces
Article Abstract:
The photoelectrochemical process, semiconductor-electrolyte interface (SEI), provides an improved method of measuring electron-transfer (ET) reactions. SEI processes exhibit variations depending on the type of semiconductor electrode and redox electrolyte employed. The electrode materialsused are composed of single crystals, polycrystalline thin films, macroscopic titanium dioxide and quantized-layers, while electrolyte redox solutions involve polymer films, diffusive, adsorbed and immobilized systems. Furthermore, monitoring the duration of photogenerated reactants determines interfacial ET reaction rates.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Electrochemical study of the pore structure of sandstone and similar media
- Abstracts: Quebrachitol: a versatile building block in the construction of naturally occurring bioactive materials. Fluorinated ylides and related compounds
- Abstracts: Fast events in protein folding: the time evolution of primary processes. Early events in RNA folding
- Abstracts: 1,1'-binaphthyl dimers, oligomers, and polymers: molecular recognition, asymmetric catalysis, and new materials
- Abstracts: Electron transfer in Ruthenium-modified proteins. Peptide-mediated intramolecular electron transfer: long-range distance dependence