Catalytic versatility, stability, and evolution of the (beta)(alpha)(sub 8)-barrel enzyme fold
Article Abstract:
The topology of the (beta)(alpha)(sub 8)-barrel fold, its distribution in nature, and some of its most remarkable catalytic performances are reviewed. The findings show that the (beta)(alpha)(sub 8)-barrel enzyme fold is particularly suitable to understand the structural basis of enzyme catalysis, stability, folding and evolution because it occurs frequently, is catalytically versatile, and harbors active sites with high functional and structural plasticity.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Catalytic promiscuity and the divergent evolution of DNA repair enzymes
Article Abstract:
The DNA repair exhibits an evolvable system, allowing for flexibility in recruiting any enzyme to a new function, so that gene duplication in a redundant DNA repair activity would not be required. Most DNA repair enzymes have broad substrate specificity, enabling an abundant source of enzymes with low promiscuity to simplify DNA repair activity.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Strategies in making cross-linked enzyme crystals
Article Abstract:
Chemical modification (super 102) of the enzymes is carried out to stabilize and modify their catalytic activity. By cross-linking the chemically modified enzyme, a new type of chemically engineered (super 103) enzyme is produced, and the cross-linked enzyme technology can be extended very well to genetically engineered enzymes.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Catalytic enantioselective C-H activation by means of metal-carbenoid-induced C-H insertion
- Abstracts: Catalytic enantioselective C-H activation by means of metal-carbenoid-induced C-H insertion. part 2 Combination of enzymes and metal catalysts. A powerful approach in asymmetric catalysis
- Abstracts: Cathode ray tube phosphors. Rational design of sequestering agents for plutonium and other actinides
- Abstracts: Lanthanides and actinides in ionic liquids. Recent developments in the synthesis and utilization of chiral sulfoxides
- Abstracts: Measurement of OH and HO2 in the troposphere. Dynamical studies of the ozone isotope effect: A status report