Diastereoselection in Lewis-acid-mediated aldol additions
Article Abstract:
The catalytic enantioselective aldol addition is one of the most important carbon-carbon bond formation reactions. However, experiments conducted on these reactions reveal that examples for a real and general asymmetric and catalytic aldol addition are rare and limited in scope. On the other hand, the application of aldolases as synthetic catalysts via Lewis acids has yielded a lot of efficient syntheses of stereochemically complex molecules. High turnover rates and enantioselectivities were observed in these processes, but the use of enzymes also has its limitations.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1999
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Pterin-dependent amino acid hydroxylases
Article Abstract:
The tetrahydrobiopterin-dependent aromatic amino acid hydroxylases hydroxylate L-Phe and L-Trp to generate similar oxygenating intermediates. Phenylalanine, tyrosine and tryptophan hydroxylases are involved in the rate-determining steps of phenylalanine catabolism, whose dysfunctioning causes phenylketonuria. A tetramer unit brings about the cooperative unit functioning in the allosteric activation of BH4-dependent catalysis.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1996
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Zinc-nucleic acid interaction
Article Abstract:
The principle of the interaction of multinuclear zinc 2+ complexes with nucleic acids is discussed. The basic studies of the intrinsic properties of zinc 2+ have led to a new area of biomimetic chemistry.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
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