Diastereoselection in Lewis-acid-mediated aldol additions

Article Abstract:

The catalytic enantioselective aldol addition is one of the most important carbon-carbon bond formation reactions. However, experiments conducted on these reactions reveal that examples for a real and general asymmetric and catalytic aldol addition are rare and limited in scope. On the other hand, the application of aldolases as synthetic catalysts via Lewis acids has yielded a lot of efficient syntheses of stereochemically complex molecules. High turnover rates and enantioselectivities were observed in these processes, but the use of enzymes also has its limitations.

Usage, Catalysis, Chemical bonds, Enantiomers, Carbon compounds, Organic acids

---

Pterin-dependent amino acid hydroxylases

Article Abstract:

The tetrahydrobiopterin-dependent aromatic amino acid hydroxylases hydroxylate L-Phe and L-Trp to generate similar oxygenating intermediates. Phenylalanine, tyrosine and tryptophan hydroxylases are involved in the rate-determining steps of phenylalanine catabolism, whose dysfunctioning causes phenylketonuria. A tetramer unit brings about the cooperative unit functioning in the allosteric activation of BH4-dependent catalysis.

Observations, Hydroxylases, Phenylalanine

---

Zinc-nucleic acid interaction

Article Abstract:

The principle of the interaction of multinuclear zinc 2+ complexes with nucleic acids is discussed. The basic studies of the intrinsic properties of zinc 2+ have led to a new area of biomimetic chemistry.

Analysis, Zinc, Nucleic acids, Chemical properties, Nucleic acid synthesis

Similar abstracts:

• Abstracts: Synthesis and diastereoselective reactions of N,N-dibenzylamino aldehydes and related compounds. Substrate-directable chemical reactions
• Abstracts: Face selection in addition and elimination in sterically unbiased systems. Asymmetric hydroformylation
• Abstracts: Structural insight into the aromatic amino acid hydroxylases and their disease-related mutant forms. Partially modified retro-inverso peptides: development, synthesis, and conformational behavior
• Abstracts: Calculation of octanol-water partition coefficients of organic solutes from their molecular volumes. Ketonization of (Z)-2-methoxy-1,2-diphenylvinyl alcohol
• Abstracts: Selectin-carbohydrate interactions: from natural ligands to designed mimics

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.