Molecular mechanisms underlying nonribosomal peptide synthesis: Approach to new antibiotics
Article Abstract:
The global overview of the understanding of natural nonribosomal peptide synthesis (NRPS) and of progress in genetically engineered and chemoenzymatic synthesis of nonribosomal peptide products is provided. NRPS are highly sophisticated natural nanomachines that were optimized for the biosynthesis of compounds that cannot be produced by the ribosomal machinery and were selected during evolution for diverse structures and for broad biological activities.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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Glycopeptide and lipoglycopeptide antibiotics
Article Abstract:
A study was conducted to explain how access to unnatural glycopeptides enabled to identify new targets of the glycopeptide class and activity differences observed for natural glycopeptides against different bacterial pathogens. Also, an analysis was made on the ways in which resistance to the glycopeptides will develop and the efforts to develop glycopeptides that can overcome resistance were summarized.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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Thiopeptide antibiotics
Article Abstract:
The thiopeptide antibiotics are naturally occuring, sulfur-containing, highly modified, macrocyclic peptides, nearly all of which inhibit protein synthesis in bacteria. The mode of action of thiopeptides for inhibition of bacterial protein synthesis, their biosynthetic mechanisms, and the origin of resistance determinants are described.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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