Molecular recognition of protein-ligand complexes: applications to drug design
Article Abstract:
The interactions of small molecule ligands with protein receptors were reported. The structures of complexes between small molecule ligands and several enzymes which are relevant as drug targets were also investigated. Examples of different ligands binding to the same protein were presented to provide analogies which should help in the structure design process and demonstrate the structural basis of peptide mimicry.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1997
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Toward intelligent molecular machines: Directed motions of biological and artificial molecules and assemblies
Article Abstract:
An overview of the studies on biological molecular machines is described with an emphasis on their programmed motions and potential applications to the fabrication of movable nanodevices. The main aim is to bring together the research areas of biological and artificial molecular devices that were discussed separately and to initiate a new paradigm for the development of intelligent nanodevices.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
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Structural basis for control by phosphorylation
Article Abstract:
Research has been conducted on the phosphorylation. The structural consequences of phosphorylation and the correlation of the structural response with signal are discussed.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2001
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- Abstracts: Enantiomeric recognition of amine compounds by chiral macrocyclic receptors. Chiral separations in capillary electrophoresis
- Abstracts: Chemical reaction dynamics beyond the Born-Oppenheimer approximation. Optical properties and ultrafast dynamics of metallic nanocrystals
- Abstracts: Luminescent and redox-active polynuclear transition metal complexes. Solvent effects on the electronic spectra of transition metal complexes
- Abstracts: Modular peptide synthetases involved in nonribosomal peptide synthesis. The chemistry of 2-aminocycloalkanecarboxylic acids