The effects of DNA covalent adducts on in vitro transcription
Article Abstract:
DNA covalent adducts suppress the rate of in vitro transcription and produce RNA chains with alterations in size, abundance, and sequence. Small monofunctional adducts, cisplatin, and the presence of bulky substituents cause premature restriction of elongation leading to a collection of short transcripts. Termination of transcription occurs during the disruption of the polynucleotide structure by covalent DNA lesions.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1996
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Preorganization of DNA: design principles for improving nucleic acid recognition by synthetic oligonucleotides
Article Abstract:
The design principles used in the construction of DNA analogues for recognizing specific DNA and RNA sequences were investigated. Molecular strategies to increase binding affinity and specificity which are important in molecular recognition were also analyzed. It was observed that preorganization strategies can create great benefits in the recognition of nucleic acids by oligonucleotides.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1997
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A structural basis for RNA-ligand interactions
Article Abstract:
Ribonucleic acid (RNA)-ligand interactions and the role of RNA tertiary structure and specific binding modes were investigated. High resolution structures and indirect biochemical data on RNA-ligand interactions were also analyzed. It was found that RNA has the ability to form an array of tertiary structures and specific binding pockets for small molecules and catalytic cofactors.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1997
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