Hemochromatosis and iron needs
Article Abstract:
Iron requirements in the body and hemochromatosis, or iron overload, have been studied relative to a mutation shown to exist in an MHC Class I-like gene (HFE). The HFE gene encodes for a 343-amino-acid protein, HFE. The mutation has been found at the 80-100% level in some groups with the disease, but 18-20% of patients with the mutation did not show significant iron overload. Normal iron metabolism, porphyria cutanea tarda, and factors influencing iron storage are discussed.
Publication Name: Nutrition Reviews
Subject: Food/cooking/nutrition
ISSN: 0029-6643
Year: 1998
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Immunotoxicology: hazard identification and risk assessment
Article Abstract:
Data studying the consequences of toxic substances such as drugs, chemicals and environmental toxins on animals should be used as a knowledge base for studies in human toxicology. Studies over the last 20 years indicate a correlation between a suppressed immune function and altered host defense. Studies in the new science of immunotoxicology could aid in risk assessment.
Publication Name: Nutrition Reviews
Subject: Food/cooking/nutrition
ISSN: 0029-6643
Year: 1998
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